Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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Rebound tenderness or hepatosplenomegaly was not found.

In conclusion, XGC is difficult to differentiate from other forms of cholecystitis and, sometimes, from gallbladder cancer, clinically and radiologically. No metaplasia, nuclear atypia or dysplasia is apparent. Address reprint requests to: There were also multiple black pigmented gallstones ranging from 0.

It has been suggested that xanthogranulomatous cholecystitis can be divided into two forms: Retrieved from ” https: Acute cholecystitis ; Acalculous cholecystitis ; Emphysematous cholecystitis ; Eosinophilic Cholescystitis ; Necrobiotic Xanthogranuloma of the the skin.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Ceroidlike histiocytic granulomas of gallbladder. A prospective study of 31 cases.

Xanthogranulomatous cholecystitis mimicking stage IV gallbladder cancer. Hepatobiliary Pancreat Dis Int 11 5: A clinicopathological study of 20 cases and review of the literature. Histologically, the nodules are predominantly composed of abundant lipid-laden macrophages, inflammatory cells and fibroblasts. Therefore, before the operation, differential diagnosis of XGC xanthogranulomayous gallbladder cancer by percutaneous needle biopsy might be helpful in planning the appropriate operative procedure.


Foamy macrophages or macrophages with ceroid, bile or iron Also cholesterol clefts and multinucleated giant cells May be focal, nodular or diffuse May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils.

Xanthogranulomatous cholecystitis – Libre Pathology

Nippon Geka Gakkai Zasshi. Surgical treatment of xanthogranulomatous cholecystitis: Xanthogranulomatous cholecystitis in laparoscopic surgery. Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement Fig. Magnetic resonance imaging MRI demonstrated diffuse wall thickening of the gallbladder by viewing high signal foci danthogranulomatous signal void lesions Fig.

Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm. Gallstones are present in most cases. It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall We report a case with XGC mimicking gallbladder cancer in a hemophilia patient.

On admission, the patient was febrile and had tenderness on deep palpation to the right upper quadrant.

The true incidence of XGC is difficult to establish because this disease is apparently a rare condition, although retrospective estimates of the incidence in cholecystectomy specimens range from 0. A year-old male was admitted to Chonnam National University Hospital with a day history of right upper quadrant pain with fever. This is usually seen in association with dense fibrous tissue. Eur J Radiol 82 9: This page was last modified on 30 Mayat Click here for information on linking to our website or using our content or images.


Xanthogranulomaatous tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement. Fligial S, Lewin KJ. There was a small-sized abscess in the gallbladder wall near the cystic duct.

J Indian Med Assoc ; Xanthogranulomatous cholecystitis may form cholecystifis tumour-like mass in inflamed gallbladders. They are likely to be complicated by the presence of dense fibrous adhesions, abscess and adherence of the gallbladder to adjacent structures.

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Infectious etiology of xanthogranulomatous cholecystitis: Hepatobiliary Pancreat Dis Int. Accessed December 31st, J Radiol Case Rep 5 4: The sections show a thickened gallbladder wall with cholesterol clefts, multinucleated giant cells, cholecystjtis and lymphoid aggregates. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.