Blinded MRI analysis demonstrated that BST-CarGel®-treated patients showed a significantly greater treatment effect for lesion filling (P = ) over 5 years. BST-CarGel is an advanced bioscaffold technology for enhancing cartilage regeneration. BST-CarGel was developed to stabilize the blood clot in the cartilage lesion by dispersing a soluble and adhesive polymer scaffold containing chitosan.
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Correlation between magnetic resonance imaging and clinical outcomes after cartilage repair surgery in the knee: J Bone Joint Surg Br. Impedes blood clot retraction while allowing for normal clotting to occur. General estimating equations were used for longitudinal statistical analysis of repeated measures.
Second, optimal MFX surgical technique was strictly obeyed in both groups. Debrided lesions quantified using 1-month posttreatment scans represented baseline values for lesion surface area and volume. Author information Copyright and License information Disclaimer.
Results Enrollment and Baseline Characteristics of the Patients Screening and enrollment for the initial 1-year trial took place from May cafgel Januaryand 1-year follow-up was concluded in February Lower negative scores indicate better results. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage.
BST-CarGel ® – Smith & Nephew – PDF Catalogs | Technical Documentation
None of the characteristics were found to be significant covariates leading to bias during sensitivity analyses, despite reports that clinical outcomes after microfracture are age dependent.
Trial Detail – UK Clinical Trial Gateway
A polarized light microscopy method for accurate and reliable grading of collagen organization in cartilage repair. Check availability of results on the Clinicaltrials. This interpretation for T2 MRI and its relationship to collagen organization is substantiated by a previous statistical correlation between T2 and polarized light microscopy scoring of 38 repair tissue biopsies retrieved at 1 year posttreatment in this same study.
Ultimately, the determination of what factors are predictive of clinical outcome following cartilage repair will be multivariate, considering the numerous patient-specific and cartilage lesion—specific variables. Repair tissue quantity and quality; Up to 24 months post-surgery; Adverse events related to treatment; Up to 24 months post-surgery; Economic evaluation; surgical visit, 2 weeks, 6 weeks, 3 months, 6 months, 9 months,12 months and 24 months post-surgery.
Microfracture technique versus osteochondral autologous transplantation mosaicplasty in patients with articular chondral lesions of the knee: Current concepts in the rehabilitation following articular cartilage repair procedures in the knee. This article has been cited by other articles in PMC.
Effects of calcified cartilage on healing of chondral defects treated with microfracture bts horses. Histologic analysis of tissue after failed cartilage repair procedures.
The natural history of cartilage defects in people with knee osteoarthritis. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: Clinical benefit was evaluated as a secondary outcome at initiation, 2, 3, 4, and 5 years posttreatment using the WOMAC questionnaire consisting of 3 subscales: This report was undertaken to investigate 5-year structural and clinical outcomes. One or more of the authors received payments, either directly or indirectly i.
Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.
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Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee? There is currently no consensus regarding the optimal patient-based instruments for outcome assessments in cartilage repair. Knee Surg Cargfl Traumatol Arthrosc.
Shive1 William D.
You are sending them the link for the trial open on this page. Leave undisturbed for a minimum of 10 minutes. T2 or transverse relaxation time is well known to be sensitive to, and highly dependent on, the extracellular cartilage matrix and particularly the collagen network structure, orientation, as well as macromolecular concentration, and tissue hydration.
BST-CarGel Piramal Life Sciences, Bio-Orthopaedic Divisiona liquid chitosan-containing polymer scaffolding, has been developed as an intra-articular injectable scaffold to aid in the stabilization of the blood clot created by microfracture. Treatment of symptomatic cartilage defects of the knee: Food and Drug Administration. Applications of chitin and chitosan for biomaterials. Study Design and Participants The initial 1-year trial 26 enrolled 80 patients at 26 clinical sites.
Journal List Cartilage v. Unique to this trial was the new level of evidence brought by the use of validated 3-dimensional quantitative MRI, which assessed the structural outcomes of repair tissue quantity and quality over 5 years with a high level of standardization and precision not previously achieved in a Good Clinical Practice—compliant RCT for cartilage repair.
J Bone Joint Surg Am ;